Products for Research Use Only
RegisterLogin

CK-666

CAT: 0931-T10826-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T10826-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
442633-00-3
Target
Arp2/3 Complex, Microtubule Associated, HIV Protease
Related Pathways
Cytoskeletal Signaling, Microbiology/Virology, Proteases/Proteasome
Purity
0.9993
Bioactivity
CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.
Smiles
Cc1[nH]c2ccccc2c1CCNC(=O)c1ccccc1F
Molecular Formula
C18H17FN2O
Molecular Weight
296.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CK-666

CK-666 is a member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. It has a role as an actin polymerisation inhibitor. It is a member of benzamides, a member of indoles and an organofluorine compound.

CAS Number442633-00-3
PubChem CID589075
IUPAC Name2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Molecular FormulaC18H17FN2O
Molecular Weight296.3
XLogP3.8
Topological Polar Surface Area44.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity389
SMILES
CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
InChI
InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChIKey
UXRKUKRXVWJFER-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CK-666
CAS: 442633-00-3
CID: 589075
Formula: C18H17FN2O
MW: 296.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass296.13249133
Monoisotopic Mass296.13249133
Topological Polar Surface Area44.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T87874-01AXC-666
T5318-01666-15
T30954CK 2130
T30957CK 492B
T5860-01CK-869
T86064-01CK-963
T30956-01CK 3197
T30958CK 683A
T30955-01CK 2289
T30959-01CK-119

Alternative Products

CatalogName
MBS3604507-01CK 666
GTR19176874-01CK-666
A20973-200CK-666 200mg
A20973-10CK-666 10mg

Popular Products