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Tozasertib (VX-680)

CAT: 1568-C07469-1gSize: 1 gDry Ice: YesHazardous: No
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CAT#:1568-C07469-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
639089-54-6
Synonyms
MK-0457
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
CC1=CC (=NN1) NC2=CC (=NC (=N2) SC3=CC=C (C=C3) NC (=O) C4CC4) N5CCN (CC5) C
Molecular Formula
C23H28N8OS
Additionnal Information
Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent

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Alternative Products

CatalogName
S1048-250mgTozasertib (VX-680)
MBS385761-01VX-680 (MK-0457, Tozasertib)
A4111-100VX-680 (MK-0457,Tozasertib)
MBS576873VX-680 (Tozasertib, MK-0457)
1595-25Tozasertib (VX-680, MK-0457, VX6)
T8078-01Tozasertib, Free Base (N-[4-[[4- (4-methylpiperazin-1-yl) -6-[ (5-methyl-1H-pyrazol-3-yl) amino]pyrimidin-2-yl]sulfanyl]phenyl]cyclopropanecarboxamide, VX-680, MK-0457, VX6)
MBS655388-01Tozasertib, Free Base (N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanyl]phenyl]cyclopropanecarboxamide, VX-680, MK-0457, VX6)
FM28353VX 680
MBS130848-01VX-680
A10981-100VX-680 100mg

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