VX-984

• CAS Number :

  1476074-39-1

• Synonyms :

  M9831

• SKU :

  C13524-1mg

• Target :

  DNA-PK

• Applications :

  PI3K/Akt/mTOR

• Molecular Formula :

  C23H21D2N7O

• Additionnal Information :

  VX-984 (M9831) is an orally active, potent, selective, and ATP-competitive inhibitor of DNA-PK. VX-984 effectively suppresses non-homologous end joining (NHEJ) and increases DNA double-strand breaks (DSBs) . It enhances the cytotoxic effects of ionizing radiation (IR) in various cancer cell lines, including non-small cell lung cancer (NSCLC) cell lines, in vitro. Additionally, VX-984 reduces DNA-PKcs autophosphorylation.