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Compound E

CAT: 1568-C06975-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C06975-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
209986-17-4
Synonyms
γ-Secretase-IN-1
Target
Secretase
Applications
Stem Cells & Wnt
Molecular Formula
C27H24F2N4O3
Additionnal Information
Compound E (γ-Secretase-IN-1) is a potent inhibitor of γ-secretase, which blocks γ-secretase-mediated cleavage of Notch with an IC50 of 0.32 nM. It also suppresses the production of β-amyloid (40) and β-amyloid (42) with IC50 values of 0.24 nM and 0.37 nM, respectively. It also inhibits Notch signalling, significantly disrupting gonadotropin-dependent follicle growth and halting progression to the preovulatory stage of development.

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