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LDN-212320

CAT: 0804-HY-12741-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12741-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1) /excitatory amino acid transporter 2 (EAAT2) activator (at translational level) . LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC[1][2].
CAS Number
894002-50-7
Product Name Alternative
LDN-0212320; OSU-0212320
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LDN-212320.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=CC=CC=C1CSC2=NN=C(C3=NC=CC=C3)C=C2
Molecular Formula
C17H15N3S
Molecular Weight
293.39
Precautions
H302, H315, H319
References & Citations
[1]Ghallab Alotaibi, et al. Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice. Eur J Pain. 2019 Apr;23 (4) :765-783.|[2]Xuechao Xing, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 1;21 (19) :5774-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EAAT2

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