Z-Nle-Lys-Arg-AMC (acetate)

• UNSPSC Description:

  Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range[1].

• Target Antigen:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/z-nle-lys-arg-amc-acetate.html

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  CCCC[C@@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC1=CC(O2)=C(C=C1)C(C)=CC2=O)=O)=O)CCCCN)=O)NC(OCC3=CC=CC=C3)=O.CC(O)=O.[x]

• Molecular Weight:

  706.83 (free base)

• References & Citations:

  [1]Yoon MC, et al. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 Aug 1;62(15):2289-2300.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported