Z-Gly-Gly-Arg-AMC (acetate)

• UNSPSC Description:

  Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

• Target Antigen:

  Fluorescent Dye

• Type:

  Dye Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/Z-Gly-Gly-Arg-AMC-acetate.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 20 mg/mL (ultrasonic)

• Smiles:

  CC(O)=O.O=C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)=O)=O)OCC3=CC=CC=C3

• Molecular Weight:

  639.66

• References & Citations:

  [1]Tarandovskiy ID, et al. Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. PLoS One. 2013;8(2):e55688.|[2]Machlus KR, et al. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov;102(5):936-44.Acta Pharmacol Sin. 2024 Jun 24.|Bioorg Chem. 2019 Nov;92:103199. |Chem Biol Interact. 2023 Apr 18;110501.|J Mater Chem B. 2017 Oct 14;5(38):7876-7884. |RSC Adv. 2020, 10(7):3626-3635.|Spectrochim Acta A Mol Biomol Spectrosc. 6 August 2021, 120250.|Int J Biol Macromol. 2019 Aug 1;134:622-630. |Int J Biol Macromol. 2019 Sep 15;137:261-269.|Phytochemistry. 2019 Jun 14;165:112025.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2070009-61-7