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Z-Ala-Arg-Arg-AMC

CAT: 0804-HY-134961-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134961-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome[1].
CAS Number
90468-18-1
Product Name Alternative
Fluorogenic Proteasome Substrate; Z-ARR-AMC
UNSPSC
12352209
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/z-ala-arg-arg-amc.html
Purity
98.41
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)C=C1O3)=CC3=O
Molecular Formula
C33H44N10O7
Molecular Weight
692.77
References & Citations
[1]Crawford LJ, et al. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006 Jun 15;66 (12) :6379-86.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Z-Ala-Arg-Arg-AMC
CAS Number90468-18-1
PubChem CID25108603
IUPAC Namebenzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]carbamate
Molecular FormulaC33H44N10O7
Molecular Weight692.8
XLogP-0.3
Topological Polar Surface Area281
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count9
Rotatable Bond Count18
Heavy Atom Count50
Formal Charge0
Complexity1280
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)OCC3=CC=CC=C3
InChI
InChI=1S/C33H44N10O7/c1-19-16-27(44)50-26-17-22(12-13-23(19)26)41-29(46)24(10-6-14-38-31(34)35)43-30(47)25(11-7-15-39-32(36)37)42-28(45)20(2)40-33(48)49-18-21-8-4-3-5-9-21/h3-5,8-9,12-13,16-17,20,24-25H,6-7,10-11,14-15,18H2,1-2H3,(H,40,48)(H,41,46)(H,42,45)(H,43,47)(H4,34,35,38)(H4,36,37,39)/t20-,24-,25-/m0/s1
InChIKey
RACPARIFVUIBCA-OPXMRZJTSA-N
Chemical Structure
2D Structure
2D structure of Z-Ala-Arg-Arg-AMC
CAS: 90468-18-1
CID: 25108603
Formula: C33H44N10O7
MW: 692.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight692.8
XLogP3-0.3
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count9
Rotatable Bond Count18
Exact Mass692.33944378
Monoisotopic Mass692.33944378
Topological Polar Surface Area281 Ų
Heavy Atom Count50
Formal Charge0
Complexity1280
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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