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Chloroquine dihydrochloride

CAT: 1568-C15168-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C15168-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3545-67-3
Target
Autophagy
Applications
Autophagy
Molecular Formula
C18H26ClN3.2ClH
Additionnal Information
Chloroquine dihydrochloride acts as an inhibitor of autophagy and toll-like receptors (TLRs) . Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
Storage Conditions
2 years -20°C liquid

Chemical Information

Chloroquine Hydrochloride

Chloroquine Hydrochloride is the hydrochloride salt of chloroquine, a synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

CAS Number3545-67-3
PubChem CID83820
IUPAC Name4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
Molecular FormulaC18H28Cl3N3
Molecular Weight392.8
Topological Polar Surface Area28.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Heavy Atom Count24
Formal Charge0
Complexity309
SMILES
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.Cl.Cl
InChI
InChI=1S/C18H26ClN3.2ClH/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;;/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*1H
InChIKey
PCFGECQRSMVKCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Chloroquine Hydrochloride
CAS: 3545-67-3
CID: 83820
Formula: C18H28Cl3N3
MW: 392.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass391.134881
Monoisotopic Mass391.134881
Topological Polar Surface Area28.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity309
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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