Chloroquine

• Description:

  Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) [1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Autophagy; HIV; Parasite; SARS-CoV; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Autophagy; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/chloroquine.html

• Purity:

  99.82

• Solubility:

  DMSO : 200 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  CC (NC1=CC=NC2=CC (Cl) =CC=C12) CCCN (CC) CC

• Molecular Formula:

  C18H26ClN3

• Molecular Weight:

  319.87

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193 (12) :6135-43.|[2]Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6 (6) :1665-1672.|[3]Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.|[4]Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55 (4) :105932.|[5]Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20 (3) :131-135.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  HIV-1; Plasmodium

• Citation 01:

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• CAS Number:

  54-05-7