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AMG 410

CAT: 1568-C03728-1mgSize: 1 mgDry Ice: NoHazardous: No
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CAT#:1568-C03728-1mgSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3040175-17-2
Target
Ras
Applications
Apoptosis
Molecular Formula
C31H32ClF2N7O5
Additionnal Information
AMG410 is a non-covalent, selective inhibitor of pan-KRAS with IC50 of 1–4 nM for KRAS G12D, G12V, and G13D. It binds both GDP- and GTP-bound KRAS with Kd of 1 nM and 22 nM, respectively. AMG410 inhibits KRAS signaling in a nucleotide cycling-independent manner. It also suppresses proliferation in KRAS-amplified wild-type tumor cells.

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