GAPDH-IN-1

CAT: 0804-HY-171036-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-171036-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity) . GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].
CAS Number
[252212-58-1]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gapdh-in-1.html
Purity
98.1
Smiles
C1(C2=CC(OCC3OC3)=CC=C2)=NN=C(C4=CC(OCC5OC5)=CC=C4)O1
Molecular Formula
C20H18N2O5
Molecular Weight
366.37
References & Citations
[1]Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17 (2) :340-347.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P2804-01GAPDH, rabbit muscle
HY-P74129-01GAPDH, Mouse (His)
HY-P86316-01GAPDH Antibody (YA6008, Rabbit)
HY-P80954-01GAPDH Antibody (YA848, Mouse)
HY-P72201-01GAPDH, Human (His-SUMO)
HY-P80137-01GAPDH Antibody (YA418, Rabbit)
HY-P83944-01GAPDH Antibody (YA3641, Mouse)
HY-P78776-01GAPDH, Human (HEK293, His)
HY-P80954A-01GAPDH Antibody (HRP, YA874, Mouse)
HY-P85721Drosophila Melanogaster GAPDH Antibody (YA5413, Mouse)

Alternative Products

CatalogName
MF-0112316-01GAPDH-IN-1
M00227-6Anti-GAPDH Antibody (monoclonal, GAPDH-71.1)
PVT38216pExpress-1-Gapdh Plasmid
MBS8533635-01GAPDH

Popular Products