Wu-5

• UNSPSC Description:

  Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis[1].

• Target Antigen:

  AMPK; Apoptosis; FLT3

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/wu-5.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC

• Molecular Weight:

  351.33

• References & Citations:

  [1]Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2630378-05-9