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VSTx-3

CAT: 0804-HY-P5916Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5916Size:1 Each
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Description
VSTx-3 is a KV channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC50 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels) .
Product Name Alternative
κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; Voltage sensor toxin 3; Peptide F
UNSPSC
12352209
Target
Others; Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vstx-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2CCCCN)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(O)=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC%12=CNC%13=CC=CC=C%12%13)C(O)=O)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C182H261N51O51S6
Molecular Weight
4171.72
References & Citations
[1]Ronit S Cherki, et al. Two tarantula venom peptides as potent and differential Na (V) channels blockers. Toxicon. 2014, 58.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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