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Midodrine

CAT: 0926-FA157966-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0926-FA157966-01Size:5 mg
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CAS Number
42794-76-3
Synonyms
2-Amino-N-[2- (2,5-dimethoxyphenyl) -2-hydroxyethyl]-acetamide
MDL Number
MFCD00865849
Smiles
COC1=CC (=C (C=C1) OC) C (CNC (=O) CN) O
Molecular Formula
C12H18N2O4
Molecular Weight
254.28 g/mol
Controlled
No

Chemical Information

Midodrine

Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a sympathomimetic agent, an alpha-adrenergic agonist, a prodrug and a vasoconstrictor agent. It is an amino acid amide, an aromatic ether and a secondary alcohol. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+).

CAS Number42794-76-3
PubChem CID4195
IUPAC Name2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Molecular FormulaC12H18N2O4
Molecular Weight254.28
XLogP-0.6
Topological Polar Surface Area93.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count18
Formal Charge0
Complexity262
SMILES
COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
InChI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
InChIKey
PTKSEFOSCHHMPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Midodrine
CAS: 42794-76-3
CID: 4195
Formula: C12H18N2O4
MW: 254.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight254.28
XLogP3-0.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass254.12665706
Monoisotopic Mass254.12665706
Topological Polar Surface Area93.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity262
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP10477-01Midodrine
C4493-250Midodrine (hydrochloride)
282887-01Midodrine hydrochloride
A17758-25Midodrine 25mg
A17758-10Midodrine 10mg
A17758-5Midodrine 5mg
sc-211910Midodrine, Hydrochloride
A17758-100Midodrine 100mg
MBS575213Midodrine HCl

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