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Micrococcin P1

CAT: 0804-HY-125728-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-125728-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].
CAS Number
67401-56-3
UNSPSC
12352005
Target
Antibiotic; Bacterial; HCV; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/micrococcin-p1.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O
Molecular Formula
C48H49N13O9S6
Molecular Weight
1144.37
References & Citations
[1]Lee M, et al. Micrococcin P1, a naturally occurring macrocyclic peptide inhibiting hepatitis C virus entry in a pan-genotypic manner. Antiviral Res. 2016 Aug;132:287-95.|[2]Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo (vi) catalyst. Chem Sci. 2018 Dec 3;10 (7) :1971-1975.|[3]Carnio MC, et al. Pyridinyl polythiazole class peptide antibiotic micrococcin P1, secreted by foodborne Staphylococcus equorum WS2733, is biosynthesized nonribosomally. Eur J Biochem. 2001 Dec;268 (24) :6390-401.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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