TTA-P1

• Description:

  TTA-P1 is a potent state-independent compound inhibiting human T-type calcium channel. T-type calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. TTA-P1 has the potential for the research of absence epilepsy[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tta-p1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC (C (NC[C@H]2CCN (CCC (C) (C) C) C[C@H]2F) =O) =CC (Cl) =C1

• Molecular Formula:

  C19H27Cl2FN2O

• Molecular Weight:

  389.33

• References & Citations:

  [1]Uebele VN, Nuss CE, Fox SV, et al. Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys. 2009;55 (2) :81-93.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  T-type calcium channel

• CAS Number:

  918333-06-9