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3-Hydroxykynurenine

CAT: 0804-HY-113294-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113294-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].
CAS Number
484-78-6
Product Name Alternative
3-Hydroxy-DL-kynurenine
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Endogenous Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-hydroxykynurenine.html
Purity
99.90
Solubility
1M HCl : 33.33 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C(N)CC(C1=CC=CC(O)=C1N)=O
Molecular Formula
C10H12N2O4
Molecular Weight
224.21
Precautions
H315, H319, H335
References & Citations
[1]S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70 (1) :299-307.|[2]Sarah S Zaher, et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52 (5) :2640-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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