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Flavanone

CAT: 0804-HY-N7128-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7128-03Size:500 mg
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Description
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) . Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].
CAS Number
487-26-3
UNSPSC
12352005
Hazard Statement
H290, H314
Target
Cytochrome P450; ERK; MMP; NF-κB; p38 MAPK; PAI-1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flavanone.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CC(C2=CC=CC=C2)OC3=CC=CC=C13
Molecular Formula
C15H12O2
Molecular Weight
224.26
Precautions
H290, H314
References & Citations
[1]JT Kellis Jr, et al. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep. 225 (4666) :1032-1034.|[2]Hsiao YC, et al., Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 May 1;167 (3) :193-206.|[3]Hsiao YC, et al., The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. J Biomed Sci. 2007 Jan;14 (1) :107-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1

Chemical Information

Flavanone

Flavanone is the simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4. It derives from a hydride of a flavan.

CAS Number487-26-3
PubChem CID10251
IUPAC Name2-phenyl-2,3-dihydrochromen-4-one
Molecular FormulaC15H12O2
Molecular Weight224.25
XLogP3.2
Topological Polar Surface Area26.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity281
SMILES
C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3
InChI
InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2
InChIKey
ZONYXWQDUYMKFB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flavanone
CAS: 487-26-3
CID: 10251
Formula: C15H12O2
MW: 224.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.25
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass224.083729621
Monoisotopic Mass224.083729621
Topological Polar Surface Area26.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity281
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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