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Vitronectin Antibody (Polyclonal)

CAT: 1008-A319Size: 1.0 mLDry Ice: NoHazardous: No
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CAT#:1008-A319Size:1.0 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In contrast to membrane-formed C5b-9 complexes, C5b-9 complexes formed in the fluid phase contain an additional protein, the S protein. Subsequently, it was found that isolated S protein inhibited C5b-9 attachment. S protein functions like a “membrane analogue” in that it binds to the binding site generated on assembly of C5b-9 and is required for insertion of the complex into the membrane. As a result, SC5b-7, SC5b-8 or SC5b-9 complexes are formed which have lost their membrane-binding capacity. When the S protein was cloned and sequenced, it was found to be identical to Vitronectin. Within the complement cascade, Vitronectin not only inhibits attachment of C5b-9 to target cells, but also prevents C9 polymerization. The biological function of Vitronectin is to minimize complement-mediated attack of cells near an ongoing complement attack.
Description
A rabbit antiserum raised against human complement Vitronectin protein.
Cross Reactivity
Human
Immunogen
Highly purified human Victronectin
Clonality
Polyclonal
Source
Rabbit
Applications
See citations and technical data sheet for application info.
Concentration
> 40 mg/mL
Form
Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Storage Conditions
Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.
Specificity
The Anti-Human Vitronectin polyclonal antisera was tested by immunodiffusion methods and determined to be monospecific for the Vitronectin protein.
Isotype
Rabbit IgG
Conjugate
Unconjugated

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