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C2 Antibody (Polyclonal)

CAT: 1008-A303Size: 1.0 mLDry Ice: NoHazardous: No
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CAT#:1008-A303Size:1.0 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C2 is a polypeptide, which is present in normal human serum/plasma at approximately 20 μg/mL. This complement protein is synthesized in a variety of locations throughout the body with the main site of synthesis being the liver. It has an approximate molecular weight of 100 kD, however, the molecular weight can vary due to the natural glycosylation of the protein at 8 different sites. C2 is a key component in both the classical and lectin pathways of complement activation, as the fragments are utilized to form both the C3 and C5 convertases after C2 is cleaved to produce C2a and C2b. These fragments have molecular weights of approximately 70 kD and kD, respectively. C2a binds to C4b to form the C3 convertase, and then the C2a, C4b complex binds to C3b to form the C5 convertase. Formation of both convertase molecules is essential to the continuation of the complement cascade, with the final results being the formation of the Membrane Attack Complex, or MAC.
Description
Purified Ig from goat antiserum raised against human C2 protein.
Cross Reactivity
Human
Immunogen
Highly purified human C2 protein
Clonality
Polyclonal
Source
Goat
Applications
See citations and technical data sheet for application info.
Concentration
> 20 mg/mL
Purity
IgG Purified
Form
Liquid. Phosphate-buffered saline, pH 7.2. ≤ 0.1% Sodium Azide
Storage Conditions
Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.
Specificity
The anti-human C2s polyclonal antisera was tested against normal human serum by double immunodiffusion, quantitative radial immunodiffusion, and ELISA. The antiserum was determined to be monospecific for C2 at varying concentrations.
Isotype
Goat IgG
Conjugate
Unconjugated

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