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Cobra Venom Factor

CAT: 1008-A600Size: 1 mgDry Ice: NoHazardous: No
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CAT#:1008-A600Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cobra Venom Factor (CVF), sometimes referred to as C3b (Cobra), is the non-toxic, complement activating component of cobra venom. Like naturally occurring C3b, CVF forms a complex with complement components Factor B and Factor D. This CVFBbD convertase is capable of activating C3 in a wide variety of species via the alternative complement pathway. Unlike the naturally occurring convertase (C3bBbD), the C3b (Cobra) BbD convertase is Factor H resistant and is therefore not inactivated by Factor I or CR1. Given appropriate incubation time, CVF will convert nearly 100% of the C3 to C3 end products. Unlike CVF purified from the Naja naja haje species, CVF from Naja naja kaouthia activates the terminal pathway directly by forming a C5 convertase. This depletes C5 in a manner analogous to that described above for C3. Levels of iC3b, C3a, SC5b-9, C5a and the Factor B cleavage product Bb are all extremely high in CVF treated sera.
Description
Uniform pool of Cobra Venom Factor (CVF), a non-toxic complement activating reagent.
Source
Naja naja kaouthia (cobra)
Applications
See citations and technical data sheet for application info.
Concentration
1.0-1.2 mg/mL
Purity
≥ 95% by SDS page
Activity
8 units/mL to 20 units/mL for full complement conversion.
Form
Frozen liquid (Phosphate Buffered Saline, pH 7.2 ± 0.2)
Storage Conditions
Store at -70°C or below. Minimize freeze/thaw cycles.

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