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Factor I Protein

CAT: 1008-A411Size: 250 µLDry Ice: NoHazardous: No
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CAT#:1008-A411Size:250 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Purified human complement component Factor I. Factor I is a fluid phase complement regulatory enzyme. It consists of two peptide chains with molecular weights of 50 kD and 38 kD, respectively. Factor I is present in plasma at 35 mg/L. With Factor H, CR1 or C4 Binding Protein acting as a cofactor, Factor I cleaves the C3b subunit of the alternative and classical pathway convertases, thereby inactivating them.
Description
Purified human Factor I protein
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
>90% by SDS-PAGE
Activity
Cleaves C3b with factor H as a cofactor
Form
Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 μm filtered.
Molecular Weight
88,000 Da (2 chains)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.

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