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C1-INH Antibody (Polyclonal)

CAT: 1008-A300Size: 2.0 mLDry Ice: NoHazardous: No
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CAT#:1008-A300Size:2.0 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C1-inhibitor is a multi-specific protease inhibitor present in human plasma and serum. Normal human serum shows a concentration of approximately 200 μg/mL. C1-inhibitor is a glycoprotein with an approximate molecular weight of 110 kD. This protein contains many glycosylation sites, so the molecular weight varies depending on the quantity of sites that are glycosylated. Among the proteins regulated by C1-inhibitor are C1s and C1r of the complement complex. Regulation and inactivation of C1s and C1r effectively limits the consumption of complement components C2 and C4. Genetic deficiencies of C1-inhibitor are of two types: functional deficiencies (protein is present but not functional) and antigen deficiencies (protein is not present, or more commonly, present at a low level) . Either of these may lead to life threatening hereditary angioedema (HAE) .
Description
A goat antiserum raised against human C1 Inhibitor protein.
Cross Reactivity
Human, Baboon, Dog, Rabbit
Immunogen
Highly purified human C1-inhibitor protein
Clonality
Polyclonal
Source
Goat
Applications
See citations and technical data sheet for application info.
Concentration
> 40 mg/mL
Form
Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Storage Conditions
Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.
Specificity
The C1-inhibitor polyclonal antisera was tested against normal human plasma by double immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodiffusion, and quantitative rocket immunoelectrophoresis. The antiserum was determined to be monospecific for C1-inhibitor at varying concentrations.
Isotype
Goat IgG
Conjugate
Unconjugated

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