TP-060

TP-060

• CAS Number: 2601393-20-6
• UNSPSC Description: Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1].
• Target Antigen: Glucosylceramide Synthase (GCS)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/tp-060.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1
• Molecular Weight: 460.42
• References & Citations: [1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported