TP-060

• Description:

  Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1].

• Product Name Alternative:

  Glucosylceramide synthase-IN-1

• UNSPSC:

  12352005

• Target:

  Glucosylceramide Synthase (GCS)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tp-060.html

• Purity:

  99.31

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1

• Molecular Formula:

  C24H20F4N2O3

• Molecular Weight:

  460.42

• References & Citations:

  [1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65 (5) :4270-4290

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2601393-20-6]