AST-487 (NVP-AST487)

CAT: 0957-S6662-2mgSize: 2 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0957-S6662-2mgSize:2 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

630124-46-8

Target

FLT3

Applications

Protein Tyrosine Kinase

Smiles

CCN1CCN (CC1) CC2=C (C=C (C=C2) NC (=O) NC3=CC=C (C=C3) OC4=NC=NC (=C4) NC) C (F) (F) F

Molecular Formula

C26H30F3N7O2

Additionnal Information

AST-487 (NVP-AST487), a N, N'-diphenyl urea, is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET, KDR, c-KIT, and c-ABL kinase with IC50 values below 1 μM.

Storage Conditions

3 years -20°C powder

Chemical Information

Ast-487

antineoplastic; a RET kinase inhibitor that blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells

CAS Number	630124-46-8
PubChem CID	11409972
IUPAC Name	1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea
Molecular Formula	C26H30F3N7O2
Molecular Weight	529.6
XLogP	3.8
Topological Polar Surface Area	94.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Heavy Atom Count	38
Formal Charge	0
Complexity	730

SMILES

CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F

InChI

InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)

InChIKey

ODPGGGTTYSGTGO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 630124-46-8

CID: 11409972

Formula: C26H30F3N7O2

MW: 529.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	529.6
XLogP3	3.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	529.24130771
Monoisotopic Mass	529.24130771
Topological Polar Surface Area	94.7 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	730
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
S8682-10mM/1mL	AMG 487
S8682-1g	AMG 487
S8682-5mg	AMG 487
S8682-25mg	AMG 487
S8682-100mg	AMG 487
S8682-01	AMG 487
S8981-01	NVP-2
S1088-01	NVP-ADW742
E1609-100mg	NVP-CLR457
E1609-25mg	NVP-CLR457

Alternative Products

Catalog	Name
FAB12446-01	AST-487 (NVP-AST487)
T4053-01	AST 487
bs-75626C-01	AST-487
A15003-50	AST 487 50mg
A15003-10	AST 487 10mg
A15003-500	AST 487 500mg
A15003-5	AST 487 5mg
A15003-2	AST 487 2mg
A15003-1	AST 487 1mg

AST-487 (NVP-AST487)

Chemical Information

Related Products

Alternative Products

Popular Products