Foretinib

CAT: 0957-S1111-1gSize: 1 gDry Ice: YesHazardous: No

CAT#:0957-S1111-1gSize:1 g

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AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

849217-64-7

Synonyms

GSK1363089, EXEL-2880, XL-880, GSK089

Target

C-Met

Applications

Protein Tyrosine Kinase

Smiles

COC1=CC2=C (C=CN=C2C=C1OCCCN3CCOCC3) OC4=C (C=C (C=C4) NC (=O) C5 (CC5) C (=O) NC6=CC=C (C=C6) F) F

Molecular Formula

C34H34F2N4O6

Additionnal Information

Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Storage Conditions

2 years -80 in solvent

Alternative Products

Catalog	Name
M16164-01	Foretinib
A2974-10	Foretinib (GSK1363089)
HY-10338R-01	Foretinib (Standard)
MF-0145433-01	Foretinib phosphate
A10998-25	Foretinib 25mg

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