Foretinib

CAT: 0931-T3113-03Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0931-T3113-03Size:1 mL - 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

849217-64-7

Target

VEGFR, Tie-2, c-Met/HGFR

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.998

Bioactivity

Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.

Smiles

COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1

Molecular Formula

C34H34F2N4O6

Molecular Weight

632.65

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Foretinib

Foretinib is a quinoline substituted by 2-fluoro-4-[({1-[(4-fluorophenyl)carbamoyl]cyclopropyl}carbonyl)amino]phenoxy, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 4, 6 and 7, respectively. It is a multi-kinase inhibitor. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an apoptosis inducer and a c-Met tyrosine kinase inhibitor. It is a member of quinolines, an aromatic ether, a dicarboxylic acid diamide, a member of morpholines, a member of cyclopropanes and a member of monofluorobenzenes.

CAS Number	849217-64-7
PubChem CID	42642645
IUPAC Name	1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Molecular Formula	C34H34F2N4O6
Molecular Weight	632.7
XLogP	5.5
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	12
Heavy Atom Count	46
Formal Charge	0
Complexity	1010

SMILES

COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

InChI

InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)

InChIKey

CXQHYVUVSFXTMY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 849217-64-7

CID: 42642645

Formula: C34H34F2N4O6

MW: 632.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	632.7
XLogP3	5.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	12
Exact Mass	632.24464114
Monoisotopic Mass	632.24464114
Topological Polar Surface Area	111 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	1010
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
AR-F10770-01	Foretinib

Foretinib

Chemical Information

Alternative Products

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