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RO8191

CAT: 0957-E0448-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E0448-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
691868-88-9
Synonyms
CDM-3008, RO4948191
Target
IFN
Applications
Immunology & Inflammation
Molecular Formula
C14H5F6N5O
Additionnal Information
RO8191 (CDM-3008, RO4948191), an imidazonaphthyridine compound, is an orally active and potent agonist of interferon (IFN) receptor. RO8191 binds directly to the IFNα/β receptor 2 (IFNAR2), activating IFN-stimulated genes (ISGs) expression and the phosphorylation of JAK/STAT signaling.

Chemical Information

2-(2,4-Bis(trifluoromethyl)imidazo(1,2-a)(1,8)naphthyridin-8-yl)-1,3,4-oxadiazole
CAS Number691868-88-9
PubChem CID2768133
IUPAC Name2-[2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl]-1,3,4-oxadiazole
Molecular FormulaC14H5F6N5O
Molecular Weight373.21
XLogP3.7
Topological Polar Surface Area69.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count11
Rotatable Bond Count1
Heavy Atom Count26
Formal Charge0
Complexity531
SMILES
C1=CC2=NC(=CN2C3=C1C(=CC(=N3)C(F)(F)F)C(F)(F)F)C4=NN=CO4
InChI
InChI=1S/C14H5F6N5O/c15-13(16,17)7-3-9(14(18,19)20)23-11-6(7)1-2-10-22-8(4-25(10)11)12-24-21-5-26-12/h1-5H
InChIKey
GRHYZVJEXKTJOS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2,4-Bis(trifluoromethyl)imidazo(1,2-a)(1,8)naphthyridin-8-yl)-1,3,4-oxadiazole
CAS: 691868-88-9
CID: 2768133
Formula: C14H5F6N5O
MW: 373.21
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.21
XLogP33.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count11
Rotatable Bond Count1
Exact Mass373.03982877
Monoisotopic Mass373.03982877
Topological Polar Surface Area69.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity531
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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