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RO8191

CAT: 0804-HY-W063968-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W063968-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon[1]. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity[2].
CAS Number
[691868-88-9]
Product Name Alternative
CDM-3008; RO4948191
UNSPSC
12352005
Hazard Statement
H315, H319
Target
HBV; HCV; IFNAR; JAK; STAT
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ro8191.html
Purity
99.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F
Molecular Formula
C14H5F6N5O
Molecular Weight
373.21
Precautions
H315, H319
References & Citations
[1]Hideyuki Konishi, et al. An Orally Available, Small-Molecule Interferon Inhibits Viral Replication. Sci Rep. 2012;2:259.|[2]Yutaka Furutani, et al. An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One. 2019 Jun 12;14 (6) :e0216139.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1

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