Gamitrinib TPP hexafluorophosphate

Gamitrinib TPP hexafluorophosphate

• CAS Number: 1131626-47-5
• UNSPSC Description: Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
• Target Antigen: HSP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Gamitrinib_TPP_hexafluorophosphate.html
• Purity: 99.68
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: F[P-](F)(F)(F)(F)F.O=C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)C(NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=C(C[C@H](C[C@@H]2OC)C)C1=O
• Molecular Weight: 1036.03
• References & Citations: [1]Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121(4): 1349–1360.bioRxiv. 2024 Jan 2.|bioRxiv. 2024 September 03.|Cancer Lett. 2022 Sep 13;215915.|Clin Cancer Res. 2022 Mar 4;clincanres.0833.2021.|Elife. 2021 Jun 16;10:e63104.|Front Biosci (Landmark Ed). 2023 Sep 26, 28(9), 227.|Nature. 2020 Mar;579(7799):433-437. |Research Square Preprint. 2020 Sep.|SSRN. 2023 Jul 11.|Exp Ther Med. September 2, 2021.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported