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Cefminox (sodium)

CAT: 0804-HY-128932-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128932-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model[1][2].
CAS Number
75498-96-3
Product Name Alternative
MT-141
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Antibiotic; Bacterial; mTOR; PPAR; Prostaglandin Receptor; PTEN
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/cefminox-sodium.html
Purity
99.83
Solubility
H2O : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSC[C@@H](N)C(O)=O)=O)C1=O)O[Na]
Molecular Formula
C16H20N7NaO7S3
Molecular Weight
541.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Inouye S, et al. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26 (5) :722-9.|[2]Xia J, et al. Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IP; PPARγ

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MBS578315CEFMINOX SODIUM
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RM-C131412-01Cefminox Sodium Impurity 12
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