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(+) -EMD 57033

CAT: 0804-HY-106844A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106844A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(+) -EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+) -EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].
CAS Number
147527-31-9
UNSPSC
12352005
Hazard Statement
H302, H319, H335, H373
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/plus-emd-57033.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCCC2=C1C=CC(C3=NNC(SC3C)=O)=C2)C4=CC=C(OC)C(OC)=C4
Molecular Formula
C22H23N3O4S
Molecular Weight
425.50
Precautions
H302, H319, H335, H373
References & Citations
[1]Wang X, et al. Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033. J Biol Chem. 2001 Jul 6;276 (27) :25456-66. |[2]Ochala J, et al. EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation. Pflugers Arch. 2010 Feb;459 (3) :475-83. |[3]Hgashiyama A, et al. Effects of EMD 57033 on contraction and relaxation in isolated rabbit hearts. Circulation. 1995 Nov 15;92 (10) :3094-104. |[4]Senzaki H, et al. Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033. Circulation. 2000 Mar 7;101 (9) :1040-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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