Products for Research Use Only
RegisterLogin

EMD 53998

CAT: 0804-HY-106844-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-106844-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias[1].
CAS Number
120223-04-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/emd-53998.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OC)C=C1)N2C3=CC=C(C(C(S4)C)=NNC4=O)C=C3CCC2
Molecular Formula
C22H23N3O4S
Molecular Weight
425.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Lues I, et al., The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol. 1993 Jun;21 (6) :883-92. |[2]Uhlmann R, et al. EMD 53998 acts as Ca (2+) -sensitizer and phosphodiesterase III-inhibitor in human myocardium. Basic Res Cardiol. 1995 Sep-Oct;90 (5) :365-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PDE3

Related Products

CatalogName
HY-114987EMD 21657
HY-123356-01EMD-503982
HY-P2075EMD 55068
HY-106844A-01(+) -EMD 57033
HY-114990-01EMD 57439
HY-P2205EMD 55450
HY-10777EMD 495235
HY-19134-01EMD 56551
HY-164394EMD 1204831
HY-103247EMD 66684

Alternative Products

CatalogName
T88349-01EMD 53998

Popular Products