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SUPERKILLERTRAIL® Protein (soluble) (human), (recombinant)

CAT: 1106-ALX-201-115-3010Size: 3x 10 μgDry Ice: YesHazardous: No
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CAT#:1106-ALX-201-115-3010Size:3x 10 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
TNFSF 10, Apo-2L, CD253
Certification
RUO
UniProt
P50591
Source
Produced in E. coli . The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
Purification
Affinity purified. Sterile filtered.
Stability
Once thawed it is recommended to prepare appropriate aliquots and to store them at -80°C. In order to retain full activity aliquote concentration must be at least 0.1mg/ml; prepare 20μl aliquots and store at -80°C. Working dilution: 2-100ng/ml. Recommended: Prod. No. ALX-505-005, special storage and dilution buffer.
Concentration
0.5 mg/mL
Endotoxin
<0.01EU/μg purified protein (LAL test) .
Purity
≥98% (SDS-PAGE) . MS analysis, <1% impurity (mainly Hsp70 protein from E. coli)
Activity
Induces apoptosis at concentrations of >5ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. Shows superior activity on human cell lines that require extensive cross-linking of TRAIL-Rs for killing (e.g. Jurkat) .
Molecular Weight
~26kDa
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Notes
Click here for an example of SUPERKILLERTRAIL ® used by Eidgenössische Technische Hochschule (ETH) Zürich.
Specificity
Binds to human TRAIL receptors.
Formulation
Liquid. HEPES, pH 7.4, sodium chloride, Tween 20, sucrose, azide free and 1mM DTT.

UniProtKB · P50591

Tumor necrosis factor ligand superfamily member 10

TNF10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P50591
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFSF10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1Y9B3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Cell membraneMembraneSecreted

Molecular function

Cytokine

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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