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ALK5 Inhibitor II

CAT: 1106-ALX-270-445-M001Size: 1 mgDry Ice: NoHazardous: No
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CAT#:1106-ALX-270-445-M001Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
446859-33-2
Product Name Alternative
TGF-β RI Kinase Inhibitor II, 2- (3- (6-Methylpyridin-2-yl) -1H-pyrazol-4-yl) -1,5-naphthyridine, RepSox, E-616452, SJN 2511
Certification
RUO
Target
TGF-beta receptor
Type
Inhibitor
Stability
As indicated on product label or CoA when stored as recommended. Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C.
Purity
≥98% (HPLC)
Solubility
Soluble in DMSO (5 mg/ml) or methanol (5 mg/ml) .
Molecular Formula
C 17 H 13 N 5
Molecular Weight
287.3
Shipping Conditions
Ambient Temperature
Storage Conditions
-20°C
Appearance
White to off-white or yellow solid.
Identity
Identity determined by NMR.

Chemical Information

RepSox

RepSox is a member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a TGFbeta receptor antagonist. It is a member of pyrazoles, a member of pyridines and a 1,5-naphthyridine derivative.

CAS Number446859-33-2
PubChem CID449054
IUPAC Name2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Molecular FormulaC17H13N5
Molecular Weight287.32
XLogP2.2
Topological Polar Surface Area67.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity376
SMILES
CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
InChI
InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChIKey
LBPKYPYHDKKRFS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of RepSox
CAS: 446859-33-2
CID: 449054
Formula: C17H13N5
MW: 287.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.32
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass287.11709544
Monoisotopic Mass287.11709544
Topological Polar Surface Area67.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS696357-01ALK5 Inhibitor
sc-221234EALK5 Inhibitor II
MBS565755-01ALK5 Inhibitor I
C3656-5ALK5 Inhibitor II (hydrochloride)
SF7917-5mgA83-01 (ALK5 inhibitor)
bs-6642C-01TEW-7197, a potent ALK5 inhibitor.
TBI4546-25MGRepSox, TGFβR-1 / ALK5 inhibitor
R1035-85-01RepSox (SJN 2511, ALK5 Inhibitor II)
103-M96ALK5
BA9089-5.1ALK5-IN-34

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