AR-42

CAT: 1568-C16721-01Size: 10 mM / 1 mLDry Ice: YesHazardous: No

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CAT#:1568-C16721-01Size:10 mM / 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

935881-37-1

Synonyms

HDAC-42

SKU

C16721-50mg

Target

HDAC

Applications

DNA Damage/DNA Repair

Smiles

CC (C) C (C1=CC=CC=C1) C (=O) NC2=CC=C (C=C2) C (=O) NO

Molecular Formula

C18H20N2O3

Additionnal Information

AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.

Storage Conditions

2 years -80 in solvent

Chemical Information

Ar-42

AR-42 is a secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-3-methyl-2-phenylbutanoic acid with the amino group of 4-amino-N-hydroxybenzamide. It is a pan-HDAC inhibitor that was in clinical development for the treatment of hematological malignancies and solid tumours. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 3.5.1.98 (histone deacetylase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzenes and a hydroxamic acid.

CAS Number	935881-37-1
PubChem CID	6918848
IUPAC Name	N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide
Molecular Formula	C18H20N2O3
Molecular Weight	312.4
XLogP	2.8
Topological Polar Surface Area	78.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Heavy Atom Count	23
Formal Charge	0
Complexity	397

SMILES

CC(C)[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO

InChI

InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1

InChIKey

LAMIXXKAWNLXOC-INIZCTEOSA-N

Chemical Structure

2D Structure

CAS: 935881-37-1

CID: 6918848

Formula: C18H20N2O3

MW: 312.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	312.4
XLogP3	2.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	312.14739250
Monoisotopic Mass	312.14739250
Topological Polar Surface Area	78.4 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	397
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
C01274-5mg	NI-42
C01274-25mg	NI-42
C01274-01	NI-42
C13051-01	AR-C155858
C12683-50mg	AR-A014418
C18349-100mg	AR-C118925XX
C18349-01	AR-C118925XX
C12683-01	AR-A014418
C13051-1mg	AR-C155858
C12683-10mg	AR-A014418

Alternative Products

Catalog	Name
162671	AR-42
MBS130562-01	AR 42
2716-1	AR-42 (HDAC-42)
A11037-200	AR-42 (HDAC-42) 200mg
A11037-100	AR-42 (HDAC-42) 100mg
A11037-1	AR-42 (HDAC-42) 1mg
A11037-50	AR-42 50mg
A11037-10	AR-42 10mg
HY-171809	AR ligand 42
A11037-25	AR-42 25mg

AR-42

Chemical Information

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