VH298

CAT: 1568-C13426-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:1568-C13426-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2097381-85-4

SKU

C13426-5mg

Target

E3 Ligase

Applications

Ubiquitin

Smiles

CC1=C (SC=N1) C2=CC=C (C=C2) CNC (=O) C3CC (CN3C (=O) C (C (C) (C) C) NC (=O) C4 (CC4) C#N) O

Molecular Formula

C27H33N5O4S

Additionnal Information

VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.

Storage Conditions

3 years -20°C powder

Alternative Products

Catalog	Name
S8449-1g	VH298

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