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VH298

CAT: 0957-S8449-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S8449-02Size:25 mg
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Description
VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.
CAS Number
2097381-85-4
Target
E3 Ligase
Activity
Ubiquitin
Molecular Formula
C27H33N5O4S
Storage Conditions
3 years -20°C powder

Chemical Information

VH298

an inhibitor of von Hippel–Lindau (VHL) Cullin RING E3 ubiquitin ligase complex and probe for hypoxia inducible factor (HIF) activity

CAS Number2097381-85-4
PubChem CID122199236
IUPAC Name(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular FormulaC27H33N5O4S
Molecular Weight523.6
XLogP2.5
Topological Polar Surface Area164
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count37
Formal Charge0
Complexity931
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)C#N)O
InChI
InChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
InChIKey
NDVQUNZCNAMROD-RZUBCFFCSA-N
Chemical Structure
2D Structure
2D structure of VH298
CAS: 2097381-85-4
CID: 122199236
Formula: C27H33N5O4S
MW: 523.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight523.6
XLogP32.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass523.22532572
Monoisotopic Mass523.22532572
Topological Polar Surface Area164 Ų
Heavy Atom Count37
Formal Charge0
Complexity931
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C13426-01VH298

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