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KRIBB11

CAT: 1568-C13395-02Size: 50 mgDry Ice: YesHazardous: No
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CAT#:1568-C13395-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
342639-96-7
SKU
C13395-10mg
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CNC1=NC (=C (C=C1) [N+] (=O) [O-]) NC2=CC3=C (C=C2) NN=C3
Molecular Formula
C13H12N6O2
Additionnal Information
KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1) . KRIBB11 induces growth arrest and apoptosis.
Storage Conditions
2 years -80 in solvent

Chemical Information

Kribb11

KRIBB11 is a member of the class of indazoles that is 1H-indazole substituted by a [6-(methylamino)-3-nitropyridin-2-yl]amino group at position 5. It is an inhibitor of heat shock factor 1 (IC50 = 1.2M) and suppresses tumour growth in mouse xenograft models. It has a role as a heat shock factor 1 inhibitor, an antineoplastic agent and an apoptosis inducer. It is an aromatic amine, a C-nitro compound, an aminopyridine and a member of indazoles.

CAS Number342639-96-7
PubChem CID69894253
IUPAC Name2-N-(1H-indazol-5-yl)-6-N-methyl-3-nitropyridine-2,6-diamine
Molecular FormulaC13H12N6O2
Molecular Weight284.27
XLogP3.1
Topological Polar Surface Area111
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity376
SMILES
CNC1=NC(=C(C=C1)[N+](=O)[O-])NC2=CC3=C(C=C2)NN=C3
InChI
InChI=1S/C13H12N6O2/c1-14-12-5-4-11(19(20)21)13(17-12)16-9-2-3-10-8(6-9)7-15-18-10/h2-7H,1H3,(H,15,18)(H2,14,16,17)
InChIKey
NDJJEQIMIJJCLL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Kribb11
CAS: 342639-96-7
CID: 69894253
Formula: C13H12N6O2
MW: 284.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.27
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass284.10217365
Monoisotopic Mass284.10217365
Topological Polar Surface Area111 Ų
Heavy Atom Count21
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M14166-01KRIBB11
A16347-500KRIBB11 500mg
A16347-5KRIBB11 5mg
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A16347-100KRIBB11 100mg

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