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KRIBB11 (Standard)

CAT: 0804-HY-100872RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100872RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRIBB11 (Standard) is the analytical standard of KRIBB11 (HY-100872) . This product is intended for research and analytical applications. KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
CAS Number
[342639-96-7]
Target
Apoptosis; HSP; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
CNC1=CC=C([N+]([O-])=O)C(NC2=CC3=C(NN=C3)C=C2)=N1
Molecular Formula
C13H12N6O2
Molecular Weight
284.27
References & Citations
[1]Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286 (3) :1737-47|[2]Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87 (3) :445-55
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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