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Trilaciclib

CAT: 1568-C13387-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C13387-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1374743-00-6
Synonyms
G1T28, G1T28-1
SKU
C13387-5mg
Target
CDK
Applications
Cell Cycle
Smiles
CN1CCN (CC1) C2=CN=C (C=C2) NC3=NC=C4C=C5C (=O) NCC6 (N5C4=N3) CCCCC6
Molecular Formula
C24H30N8O
Additionnal Information
Trilaciclib is a highly potent, selective and reversible cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Trilaciclib inhibits CDK4/cyclin D1 and CDK6/cyclin D3 with IC50 of 1 nM and 4 nM, respectively.
Storage Conditions
3 years -20°C powder

Chemical Information

Trilaciclib

Trilaciclib is a member of piperazines and a member of pyridines.

CAS Number1374743-00-6
PubChem CID68029831
IUPAC Name4-[[5-(4-methylpiperazin-1-yl)-2-pyridinyl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one
Molecular FormulaC24H30N8O
Molecular Weight446.5
XLogP2.6
Topological Polar Surface Area91.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count33
Formal Charge0
Complexity707
SMILES
CN1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6
InChI
InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)
InChIKey
PDGKHKMBHVFCMG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trilaciclib
CAS: 1374743-00-6
CID: 68029831
Formula: C24H30N8O
MW: 446.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight446.5
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass446.25425761
Monoisotopic Mass446.25425761
Topological Polar Surface Area91.2 Ų
Heavy Atom Count33
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3762-50Trilaciclib
RM-T192601-01Trilaciclib Impurity 1 (N-Demethyl Trilaciclib)
B3120-5Trilaciclib dihydrochloride
A17084-50Trilaciclib 50mg
A17084-10Trilaciclib 10mg
CS-O-51863Trilaciclib D8
HY-101467RTrilaciclib (Standard)
HY-101467A-01Trilaciclib (hydrochloride)
CED49597-01Trilaciclib hydrochloride

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