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Ruxotemitide (LTX 315)

CAT: 1568-C13259-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C13259-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1345407-05-7
SKU
C13259-5mg
Target
Bcl-2
Applications
Apoptosis
Smiles
C1=CC=C (C=C1) C (C2=CC=CC=C2) C (C (=O) NC (CCCCN) C (=O) N) NC (=O) C (CC3=CNC4=CC=CC=C43) NC (=O) C (CCCCN) NC (=O) C (CCCCN) NC (=O) C (CC5=CNC6=CC=CC=C65) NC (=O) C (CC7=CNC8=CC=CC=C87) NC (=O) C (CCCCN) NC (=O) C (CCCCN) N
Molecular Formula
C78H106N18O9
Additionnal Information
Ruxotemitide (LTX 315) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
Storage Conditions
2 years -80 in solvent

Chemical Information

Ruxotemitide

LTX-315 has been used in trials studying the treatment of Cancer, Lymphoma, Melanoma, Carcinoma, and Breast Cancer, among others.

CAS Number1345407-05-7
PubChem CID46200994
IUPAC Name(2S)-2,6-diamino-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3,3-diphenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]hexanamide
Molecular FormulaC78H106N18O9
Molecular Weight1439.8
XLogP3.6
Topological Polar Surface Area479
Hydrogen Bond Donor Count18
Hydrogen Bond Acceptor Count15
Rotatable Bond Count46
Heavy Atom Count105
Formal Charge0
Complexity2670
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CNC8=CC=CC=C87)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N
InChI
InChI=1S/C78H106N18O9/c79-38-18-13-30-57(84)71(98)90-62(35-15-20-40-81)73(100)93-66(44-52-47-87-59-32-11-8-28-55(52)59)76(103)95-65(43-51-46-86-58-31-10-7-27-54(51)58)75(102)92-63(36-16-21-41-82)72(99)91-64(37-17-22-42-83)74(101)94-67(45-53-48-88-60-33-12-9-29-56(53)60)77(104)96-69(78(105)89-61(70(85)97)34-14-19-39-80)68(49-23-3-1-4-24-49)50-25-5-2-6-26-50/h1-12,23-29,31-33,46-48,57,61-69,86-88H,13-22,30,34-45,79-84H2,(H2,85,97)(H,89,105)(H,90,98)(H,91,99)(H,92,102)(H,93,100)(H,94,101)(H,95,103)(H,96,104)/t57-,61-,62-,63-,64-,65-,66-,67-,69-/m0/s1
InChIKey
GGAKLYWEFZCVIT-TVEKFXMRSA-N
Chemical Structure
2D Structure
2D structure of Ruxotemitide
CAS: 1345407-05-7
CID: 46200994
Formula: C78H106N18O9
MW: 1439.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1439.8
XLogP33.6
Hydrogen Bond Donor Count18
Hydrogen Bond Acceptor Count15
Rotatable Bond Count46
Exact Mass1438.83901703
Monoisotopic Mass1438.83901703
Topological Polar Surface Area479 Ų
Heavy Atom Count105
Formal Charge0
Complexity2670
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
S8199-1gRuxotemitide (LTX 315)
A15879-25Ruxotemitide (LTX 315) 25mg
A15879-10Ruxotemitide (LTX 315) 10mg
BUP00256LTX-315
A15879-5LTX-315 5mg
CRB1301585LTX-315 Heavy
CS-O-64038Ruxotemitide-d8
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A19389-25LTX-401 25mg
A19389-100LTX-401 100mg

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