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LTX-401

CAT: 0013-GTR19259632Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259632Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LTX-401 is a novel oncolytic amino acid derivative that specifically targets the Golgi apparatus, demonstrating significant potential in cancer therapy. In vitro studies reveal that LTX-401 effectively reduces the viability of various tumor cell lines, exhibiting cytotoxic activity across a range of concentrations. Notably, it shows the highest potency against the human malignant melanoma cell line MDA-MB-435S (IC50 = 13.5 μM) and the lowest activity against the human hepatocellular carcinoma cell line HEPG2 (IC50 = 35.4 μM) . For other cell lines, the IC50 values fall within a narrow range of 19-32 μM. Importantly, LTX-401 does not induce hemolysis in red blood cells at concentrations effective for cancer cell death, with hemolytic activity only observed at much higher concentrations (400 μg/mL = 1087 μM) . Additionally, LTX-401 demonstrates cytotoxicity against non-malignant cell lines, including HUV-EC-C endothelial cells, HaCat keratinocytes, and MRC-5 fibroblasts, suggesting a broad but selective mechanism of action.
CAS Number
1398051-86-9
Purity
>98%
Smiles
Cl.Cl.O=C (C (CN) (CCCC1C=CC=CC=1) CCCC1C=CC=CC=1) NCCN
Molecular Formula
C23H35CL2N3O
Molecular Weight
440.449504137039
Notes
For research use only.

Chemical Information

LTX-401 HCl
CAS Number1398051-86-9
PubChem CID134817186
IUPAC NameN-(2-aminoethyl)-2-(aminomethyl)-5-phenyl-2-(3-phenylpropyl)pentanamide;dihydrochloride
Molecular FormulaC23H35Cl2N3O
Molecular Weight440.4
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count3
Rotatable Bond Count12
Heavy Atom Count29
Formal Charge0
Complexity376
SMILES
C1=CC=C(C=C1)CCCC(CCCC2=CC=CC=C2)(CN)C(=O)NCCN.Cl.Cl
InChI
InChI=1S/C23H33N3O.2ClH/c24-17-18-26-22(27)23(19-25,15-7-13-20-9-3-1-4-10-20)16-8-14-21-11-5-2-6-12-21;;/h1-6,9-12H,7-8,13-19,24-25H2,(H,26,27);2*1H
InChIKey
GYDPAWIYVHOSOJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of LTX-401 HCl
CAS: 1398051-86-9
CID: 134817186
Formula: C23H35Cl2N3O
MW: 440.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count3
Rotatable Bond Count12
Exact Mass439.2157181
Monoisotopic Mass439.2157181
Topological Polar Surface Area81.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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A19389-25LTX-401 25mg
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A19389-10LTX-401 10mg
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