Products for Research Use Only
RegisterLogin

LTX-401

CAT: 0013-GTR19259632Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19259632Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LTX-401 is a novel oncolytic amino acid derivative that specifically targets the Golgi apparatus, demonstrating significant potential in cancer therapy. In vitro studies reveal that LTX-401 effectively reduces the viability of various tumor cell lines, exhibiting cytotoxic activity across a range of concentrations. Notably, it shows the highest potency against the human malignant melanoma cell line MDA-MB-435S (IC50 = 13.5 μM) and the lowest activity against the human hepatocellular carcinoma cell line HEPG2 (IC50 = 35.4 μM) . For other cell lines, the IC50 values fall within a narrow range of 19-32 μM. Importantly, LTX-401 does not induce hemolysis in red blood cells at concentrations effective for cancer cell death, with hemolytic activity only observed at much higher concentrations (400 μg/mL = 1087 μM) . Additionally, LTX-401 demonstrates cytotoxicity against non-malignant cell lines, including HUV-EC-C endothelial cells, HaCat keratinocytes, and MRC-5 fibroblasts, suggesting a broad but selective mechanism of action.
CAS Number
1398051-86-9
Purity
>98%
Smiles
Cl.Cl.O=C (C (CN) (CCCC1C=CC=CC=1) CCCC1C=CC=CC=1) NCCN
Molecular Formula
C23H35CL2N3O
Molecular Weight
440.449504137039
Notes
For research use only.

Related Products

CatalogName
GTR19163800-01LTX-315
GTR19211422-01FK-401
GTR19236991-01ST-401
GTR19172109-01Compound 401
GTR19167662-01TCS 401
GTR19157293-01TCS 401
GTR19201398-01CC-401
GTR19201208-01JX-401
GTR19163517-01FGF-401
GTR19258460-01BSI-401

Alternative Products

CatalogName
A19389-25LTX-401 25mg
A19389-100LTX-401 100mg
A19389-10LTX-401 10mg
A19389-1LTX-401 1mg
T27859-01LTX-401 HCl
A19389-50LTX-401 50mg
A19389-5LTX-401 5mg
T13759-01LTX-401 dihydrochloride (1262851-70-6 free base)
BUP00256LTX-315
A15879-5LTX-315 5mg

Popular Products