Brilanestrant (GDC-0810)

• CAS Number :

  1365888-06-7

• Synonyms :

  ARN-810

• SKU :

  C13003-5mg

• Target :

  Estrogen/progestogen Receptor

• Applications :

  Endocrinology & Hormones

• Smiles :

  CCC (=C (C1=CC=C (C=C1) C=CC (=O) O) C2=CC3=C (C=C2) NN=C3) C4=C (C=C (C=C4) F) Cl

• Molecular Formula :

  C26H20ClFN2O2

• Additionnal Information :

  Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.

• Storage Conditions :

  2 years -80 in solvent