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APTO-253

CAT: 1568-C12350-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C12350-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
916151-99-0
Synonyms
LOR-253, LT-253
SKU
C12350-5mg
Target
Myc
Applications
Apoptosis
Smiles
CC1=C (C2=NC3=C ([NH]2) C4=CC=CN=C4C5=C3C=CC=N5) C6=C ([NH]1) C=CC (=C6) F
Molecular Formula
C22H14FN5
Additionnal Information
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4) .
Storage Conditions
3 years -20°C powder

Chemical Information

Apto-253

an inducer of KLF4 transcription factor

CAS Number916151-99-0
PubChem CID11960271
IUPAC Name2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
Molecular FormulaC22H14FN5
Molecular Weight367.4
XLogP4.3
Topological Polar Surface Area70.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count28
Formal Charge0
Complexity589
SMILES
CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
InChI
InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
InChIKey
NIRXBXIPHUTNNI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Apto-253
CAS: 916151-99-0
CID: 11960271
Formula: C22H14FN5
MW: 367.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass367.12332363
Monoisotopic Mass367.12332363
Topological Polar Surface Area70.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity589
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-16291-01APTO-253
BA166663-01APTO 253
T70273-01APTO-253 HCl
T70706-01APTO-253 isomer
MBS3601776APTO-253 hydrochloride
HY-16291AAPTO-253 (hydrochloride)
ABC-TC0024A-253

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