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Mitapivat

CAT: 1568-C11958-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C11958-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1260075-17-9
Synonyms
AG-348
SKU
C11958-5mg
Target
PKM
Applications
Metabolism
Smiles
C1CC1CN2CCN (CC2) C (=O) C3=CC=C (C=C3) NS (=O) (=O) C4=CC=CC5=C4N=CC=C5
Molecular Formula
C24H26N4O3S
Additionnal Information
Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
Storage Conditions
3 years -20°C powder

Chemical Information

Mitapivat

Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red blood cells, leading to lifelong premature destruction of red blood cells or chronic hemolytic anemia. On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading to lifelong hemolytic anemia. Mitapivat has also been investigated in other hereditary red blood cell disorders associated with hemolytic anemia, such as sickle cell disease and alpha- and beta-thalassemia. On January 5, 2026, the FDA also approved the use of in the treatment of anemia in adults with alpha- or beta-thalassemia, making it the first oral treatment for this condition.

CAS Number1260075-17-9
PubChem CID59634741
IUPAC NameN-[4-[4-(cyclopropylmethyl)piperazine-1-carbonyl]phenyl]quinoline-8-sulfonamide
Molecular FormulaC24H26N4O3S
Molecular Weight450.6
XLogP1.8
Topological Polar Surface Area91
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity750
SMILES
C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5
InChI
InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2
InChIKey
XAYGBKHKBBXDAK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mitapivat
CAS: 1260075-17-9
CID: 59634741
Formula: C24H26N4O3S
MW: 450.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight450.6
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass450.17256188
Monoisotopic Mass450.17256188
Topological Polar Surface Area91 Ų
Heavy Atom Count32
Formal Charge0
Complexity750
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3846889-01Mitapivat
HY-12689CMitapivat (hydrochloride)
GTR19258718-01Mitapivat hydrochloride
HY-12689BMitapivat (hemisulfate)
TRC-M299831-10MGMitapivat-d6
A22367-500Mitapivat 500mg
A22367-10Mitapivat 10mg

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