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Mitapivat (hydrochloride)

CAT: 0804-HY-12689CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12689CSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG) . Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases[1].
CAS Number
2559738-69-9
Product Name Alternative
AG-348 (hydrochloride)
UNSPSC
12352005
Target
Pyruvate Kinase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O.[H]Cl
Molecular Formula
C24H27ClN4O3S
Molecular Weight
487.01
References & Citations
[1]Yang H, et al. Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Feb;8 (2) :246-259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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