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Mitapivat hydrochloride

CAT: 0931-T206172-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206172-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2559738-69-9
Target
PKM
Related Pathways
Metabolism
Bioactivity
Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R) . It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.
Smiles
Cl.O=C(C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC3=CC=CN=C32)N4CCN(CC4)CC5CC5
Molecular Formula
C24H27ClN4O3S
Molecular Weight
487.014
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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