Products for Research Use Only
RegisterLogin

Apilimod

CAT: 1568-C11871-03Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1568-C11871-03Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
541550-19-0
Synonyms
STA-5326
SKU
C11871-5mg
Target
PIKfyve
Applications
PI3K/Akt/mTOR
Smiles
CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4
Molecular Formula
C23H26N6O2
Additionnal Information
Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
Storage Conditions
3 years -20°C powder

Chemical Information

Apilimod

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.

CAS Number541550-19-0
PubChem CID10173277
IUPAC NameN-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Molecular FormulaC23H26N6O2
Molecular Weight418.5
XLogP3.8
Topological Polar Surface Area84.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity544
SMILES
CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
InChI
InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
InChIKey
HSKAZIJJKRAJAV-KOEQRZSOSA-N
Chemical Structure
2D Structure
2D structure of Apilimod
CAS: 541550-19-0
CID: 10173277
Formula: C23H26N6O2
MW: 418.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.5
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass418.21172409
Monoisotopic Mass418.21172409
Topological Polar Surface Area84.8 Ų
Heavy Atom Count31
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3840054-01Apilimod
407105Apilimod mesylate
7283/25Apilimod dimesylate
HY-14644BApilimod (hydrochloride)
A13794-100Apilimod 100mg
A13794-5Apilimod 5mg

Popular Products